Pharmacokinetic Demo

Digoxin Dosing

Estimates a steady-state maintenance dose (Jusko / Koup-Jusko 1-compartment model) and a weight-based loading dose, with administration notes.

DEMONSTRATION ONLY — NOT FOR CLINICAL USE

Patient

Age (years)

Weight (kg)

Height (cm)

S. creatinine (mg/dL)

Sex

Indication

Dosage form

Target serum level (ng/mL)

Result

Enter patient data and press Calculate.

Maintenance: Jusko Vd = 226 + [(298·CrCl)/(29.1+CrCl)], steady-state dose = (Css·Cl·τ)/F. CrCl by Cockcroft-Gault; lean weight by Devine. Bioavailability F: tablet 0.75, IV 1.0, elixir 0.8. Loading: weight-based (PO ~10 mcg/kg, IV ~8–12 mcg/kg lean weight). Therapeutic range 0.5–2 ng/mL; ≤0.9 ng/mL preferred.
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Not valid for dialysis, acute/unstable renal function, or interacting drugs (amiodarone, verapamil, quinidine, macrolides). Demonstration only.